The COMPASSSM Program: We’re here to help

The COMPASSSM (Comprehensive Personalized Patient Prescription Advocacy and Support Services) Program offers patients, their families, and healthcare providers one-stop convenient access to a range of support services. We also have Case Managers who are available to answer questions about the Co-Pay Assistance Program, the Patient Assistance Program, and other patient support resources.

You can enroll in COMPASSSM yourself, or your doctor can do it for you. Best of all, the services are all free.

Visit the COMPASSSM website

Once enrolled in COMPASSSM, patients can connect with a Clinical Nurse Educator who can provide personalized support, answer questions, and share helpful resources on how to manage their condition.

The Case Managers at COMPASSSM can help patients and their families gain access to ACTIMMUNE® (Interferon gamma-1b), and navigate through insurance issues and questions. The Case Managers will research your benefits and, if needed, provide assistance with prior authorizations and appeals.

COMPASSSM will help you reduce your out-of-pocket expenses through the Horizon Pharma Co-Pay Assistance Program. This program will cover the co-pay and co-insurance amounts, which will automatically be applied by the pharmacy, eliminating your monthly costs.

This Co-Pay Assistance Program is for commercial insurance plans only.

For patients who do not have insurance or whose insurance plans do not cover ACTIMMUNE® (Interferon gamma-1b), COMPASSSM may provide medication to eligible patients at no cost. At the patient's request, this program can provide assistance with finding insurance coverage.

If you have a busy schedule, sign up for text and email reminders to help you keep track of your ACTIMMUNE® (Interferon gamma-1b) refills.

Each reminder is sent 5 days before your refill is due. This is a good time to contact your specialty pharmacy to schedule your next shipment. If you have any questions, call the COMPASSSM contact number included with the reminder.

It's important that ACTIMMUNE® (Interferon gamma-1b) patients have a safe way to dispose of used syringes. Through COMPASSSM, you will automatically receive a new sharps container every 3 months with packaging so you can safely return the filled container for disposal.

*In order for patients to receive support through COMPASSSM, the prescribing physician must fax the Service Request Form to (877) 305-7706. The Co-Pay Assistance Program is not available to Medicare, Medicaid, TRICARE, or any other government-insured patients.

If you have any questions or want to make use of COMPASSSM:


Important Information About ACTIMMUNE

What is ACTIMMUNE® (Interferon gamma 1-b) used for?

ACTIMMUNE® (Interferon gamma 1-b) is part of a drug regimen used to treat Chronic Granulomatous Disease, or CGD. CGD is a genetic disorder, usually diagnosed in childhood, that affects some cells of the immune system and the body’s ability to fight infections effectively. CGD is often treated (though not cured) with antibiotics, antifungals, and ACTIMMUNE.

ACTIMMUNE is also used to slow the worsening of severe, malignant osteopetrosis (SMO). SMO is a genetic disorder that affects normal bone formation and is usually diagnosed in the first few months after birth.

When should I not take ACTIMMUNE?

Don’t use ACTIMMUNE if you are allergic to interferon-gamma, E coli-derived products, or any ingredients contained in the product.

What warnings should I know about ACTIMMUNE?

At high doses, ACTIMMUNE can cause (flu-like) symptoms, which may worsen some pre-existing heart conditions.

ACTIMMUNE may cause decreased mental status, walking disturbances, and dizziness, particularly at very high doses. These symptoms are usually reversible within a few days upon dose reduction or discontinuation of therapy.

Bone marrow function may be suppressed with ACTIMMUNE, and decreased production of cells important to the body may occur. This effect, which can be severe, is usually reversible when the drug is discontinued or the dose is reduced.

Taking ACTIMMUNE may cause reversible changes to your liver function, particularly in patients less than 1 year old. Your doctor should monitor your liver function every 3 months, and monthly in children under 1 year.

In rare cases, ACTIMMUNE can cause severe allergic reactions and/or rash. If you experience a serious reaction to ACTIMMUNE, discontinue it immediately and contact your doctor or seek medical help.

What should I tell my healthcare provider?

Be sure to tell your doctor about all the medications you are taking.

Tell your doctor if you:

  • are pregnant or plan to become pregnant or plan to nurse
  • have a cardiac condition such as irregular heartbeat, heart failure, or decreased blood flow to your heart
  • have a history of seizures or other neurologic disorders
  • have, or have had, reduced bone marrow function. Your doctor will monitor these cells with blood tests at the beginning of therapy and at 3-month intervals on ACTIMMUNE therapy
What are the side effects of ACTIMMUNE?

The most common side effects with ACTIMMUNE are “flu-like” symptoms such as fever, headache, chills, muscle pain, or fatigue, which may decrease in severity as treatment continues. Bedtime administration of ACTIMMUNE may help reduce some of these symptoms. Acetaminophen may be helpful in preventing fever and headache.

What other medications might interact with ACTIMMUNE?

Some drugs may interact with ACTIMMUNE to potentially increase the risk of damage to your heart or nervous system, such as certain chemotherapy drugs. Tell your doctor about all other medications you are taking.

Avoid taking ACTIMMUNE at the same time as a vaccination.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit, or call 1-800-FDA-1088. You may also contact the Horizon Pharma Medical Information Department toll-free at 1-866-479-6742 or medicalinformation

The risk information provided here is not comprehensive. To learn more, talk about ACTIMMUNE with your healthcare provider or pharmacist. The FDA-approved product labeling can be found at or 1-866-479-6742.