Protect yourself every day

Life choices can help protect the health of patients with Chronic Granulomatous Disease (CGD). It is very important to take steps to avoid the bacteria, fungi, molds, and yeasts that can cause infections. The Chronic Granulomatous Disease Association recommends the following precautions.1

Note: This information does not address all considerations related to living with and managing CGD, and is not a substitute for medical advice. You should always discuss your personal situation with your healthcare provider.

This list was adapted from the "After Being Diagnosed" page of the Chronic Granulomatous Disease Association website: cgdassociation.org.

your environment
  • Do not swim in lakes and rivers
  • Do not go outside with bare feet
  • Avoid working with or near mulch, hay, wood chips, grass clippings, or other yard waste
  • Do not rake leaves
  • Do not play in or around playgrounds with wood chips in the play areas. Only use playgrounds with plain dirt, rubberized surface, or gravel surfaces.
  • Stay out of barns, caves, and other dusty or damp areas
  • If you use a vaporizer, empty it daily and wash it with bleach to kill mold

This is not a complete list. Please ask your healthcare provider for more information.

Get your copy of the Lifestyle Choices guide. This may be helpful in protecting your health.

gardening
  • If possible, do not do any gardening. If you have to tend to plants or do any planting in a garden, wear a surgical mask to filter the air
  • Do not put plants in soil or transfer them from one pot to another. Harmful molds can grow in soil
  • If you have fresh cut flowers, add a teaspoon of bleach to the water to prevent mold and algae from growing. Ask a friend who does not have CGD to change the water in the vase every day

This is not a complete list. Please consult your healthcare provider for more information.

construction
  • Do not fix up old buildings
  • Do not go inside a building where construction has been done until it has been thoroughly cleaned
  • Avoid newly constructed buildings due to the dust that comes from both lumber and raw dirt
  • Do not rip up or replace carpet or tile. Have someone else do the work, and then have the rooms thoroughly cleaned with bleach before living or sleeping in them

This is not a complete list. Please consult your healthcare provider for more information.

injury and illness
  • Wash all cuts and scrapes thoroughly with soap and water. Do a final rinse with hydrogen peroxide, then apply an antiseptic such as Betadine®
  • Talk to your healthcare provider about any wound or fever

This is not a complete list. Please consult your healthcare provider for more information.

Betadine® is a registered trademark of Purdue Products LP.

pets
  • Keep pets up-to-date with all recommended vaccinations
  • Keep a pet’s water dishes and bedding clean
  • Do not use wood shavings as bedding for any pet, large or small

This is not a complete list. Please consult your healthcare provider for more information.

Miscellaneous
  • Do not smoke or inhale smoke
  • If you develop a fever, especially if accompanied by a cough, you should contact your physician immediately

This is not a complete list. Please consult your healthcare provider for more information.

Follow your healthcare provider's advice

Your healthcare provider may recommend regular follow-­up visits. These can help in detecting symptoms and complications early so that they can be managed more effectively. And as with all medications, it is important that you follow your healthcare provider's recommendations closely.

Reference: 1. After being diagnosed. Chronic Granulomatous Disease Association Web site. http://www.cgdassociation.org/afterdiagnosis.php. Accessed April 25, 2015.

IMPORTANT SAFETY INFORMATION AND INDICATIONS

Important Information About ACTIMMUNE

What is ACTIMMUNE® (Interferon gamma 1-b) used for?

ACTIMMUNE® (Interferon gamma 1-b) is part of a drug regimen used to treat Chronic Granulomatous Disease, or CGD. CGD is a genetic disorder, usually diagnosed in childhood, that affects some cells of the immune system and the body’s ability to fight infections effectively. CGD is often treated (though not cured) with antibiotics, antifungals, and ACTIMMUNE.

ACTIMMUNE is also used to slow the worsening of severe, malignant osteopetrosis (SMO). SMO is a genetic disorder that affects normal bone formation and is usually diagnosed in the first few months after birth.

When should I not take ACTIMMUNE?

Don’t use ACTIMMUNE if you are allergic to interferon-gamma, E coli-derived products, or any ingredients contained in the product.

What warnings should I know about ACTIMMUNE?

At high doses, ACTIMMUNE can cause (flu-like) symptoms, which may worsen some pre-existing heart conditions.

ACTIMMUNE may cause decreased mental status, walking disturbances, and dizziness, particularly at very high doses. These symptoms are usually reversible within a few days upon dose reduction or discontinuation of therapy.

Bone marrow function may be suppressed with ACTIMMUNE, and decreased production of cells important to the body may occur. This effect, which can be severe, is usually reversible when the drug is discontinued or the dose is reduced.

Taking ACTIMMUNE may cause reversible changes to your liver function, particularly in patients less than 1 year old. Your doctor should monitor your liver function every 3 months, and monthly in children under 1 year.

In rare cases, ACTIMMUNE can cause severe allergic reactions and/or rash. If you experience a serious reaction to ACTIMMUNE, discontinue it immediately and contact your doctor or seek medical help.

What should I tell my healthcare provider?

Be sure to tell your doctor about all the medications you are taking.

Tell your doctor if you:

  • are pregnant or plan to become pregnant or plan to nurse
  • have a cardiac condition such as irregular heartbeat, heart failure, or decreased blood flow to your heart
  • have a history of seizures or other neurologic disorders
  • have, or have had, reduced bone marrow function. Your doctor will monitor these cells with blood tests at the beginning of therapy and at 3-month intervals on ACTIMMUNE therapy
What are the side effects of ACTIMMUNE?

The most common side effects with ACTIMMUNE are “flu-like” symptoms such as fever, headache, chills, muscle pain, or fatigue, which may decrease in severity as treatment continues. Bedtime administration of ACTIMMUNE may help reduce some of these symptoms. Acetaminophen may be helpful in preventing fever and headache.

What other medications might interact with ACTIMMUNE?

Some drugs may interact with ACTIMMUNE to potentially increase the risk of damage to your heart or nervous system, such as certain chemotherapy drugs. Tell your doctor about all other medications you are taking.

Avoid taking ACTIMMUNE at the same time as a vaccination.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088. You may also contact the Horizon Pharma Medical Information Department toll-free at 1-866-479-6742 or medicalinformation
@horizonpharma.com
.

The risk information provided here is not comprehensive. To learn more, talk about ACTIMMUNE with your healthcare provider or pharmacist. The FDA-approved product labeling can be found at http://www.ACTIMMUNE.com or 1-866-479-6742.