CGD is an inherited disease passed down in the genes

How does a person get chronic granulomatous disease (CGD)? CGD is an inherited genetic disorder. This means that a person is born with the disease. There are 2 major types of CGD: X-linked and autosomal recessive.

X-linked CGD

The most common way CGD is passed down to a child is through a faulty gene on the X chromosome. If a mother is a carrier of CGD, she can pass it on to her children.

Chart that explains the genetics of X-linked chronic granulomatous disease

X = X chromosome with mutation

X = normal X chromosome

Y = Y chromosome

  • Usually only males get X-linked CGD. Males have 1 X and 1 Y chromosome, so if they get the X chromosome that doesn’t work, they will have CGD
  • A male child has a 50% chance of receiving the faulty gene and having CGD if his mother is a carrier
  • Females usually don’t get X-linked CGD because they have 2 X chromosomes. Only in rare cases, when an X chromosome becomes inactive, can they get X-linked CGD. Otherwise they can only be carriers of X-linked CGD and can pass it down to their children

Autosomal recessive CGD

CGD can also be passed down through autosomal recessive inheritance. This means that the person with CGD has 2 faulty genes, 1 from each parent.

Chart that explains the genetics of autosomal recessive chronic granulomatous disease

G = normal gene

g = defective gene

  • Autosomal recessive CGD is different from X-linked CGD because the faulty gene is not on the X chromosome
  • Both males and females have a 25% chance of getting autosomal recessive CGD if their parents are both carriers

Being a carrier of CGD

A carrier of CGD is a person who has 1 normal copy of the gene from 1 parent and a copy of the gene that doesn’t work from the other parent.

  • Female carriers of CGD may have lupus-like symptoms, such as skin rash and severe joint pain
  • Many women discover they are a CGD carrier after their child is diagnosed with the disease. Other women learn they are a carrier after trying to find a treatment for symptoms they can’t explain
  • There are tests that can determine if you are a carrier
Please talk to your doctor about available tests and if they are right for you.

Important Safety Information

What is ACTIMMUNE® (Interferon gamma-1b) used for?

ACTIMMUNE® is part of a drug regimen used to treat Chronic Granulomatous Disease, or CGD. CGD is a genetic disorder, usually diagnosed in childhood, that affects some cells of the immune system and the body's ability to fight infections effectively.

Important Safety Information

What is ACTIMMUNE® (Interferon gamma-1b) used for?

ACTIMMUNE® is part of a drug regimen used to treat Chronic Granulomatous Disease, or CGD. CGD is a genetic disorder, usually diagnosed in childhood, that affects some cells of the immune system and the body's ability to fight infections effectively. CGD is often treated (though not cured) with antibiotics, antifungals, and ACTIMMUNE.

ACTIMMUNE is also used to slow the worsening of severe, malignant osteopetrosis (SMO). SMO is a genetic disorder that affects normal bone formation and is usually diagnosed in the first few months after birth.

When should I not take ACTIMMUNE?

Don't use ACTIMMUNE if you are allergic to interferon-gamma, E coli-derived products, or any ingredients contained in the product.

What warnings should I know about ACTIMMUNE?

At high doses, ACTIMMUNE can cause (flu-like) symptoms, which may worsen some pre-existing heart conditions.

ACTIMMUNE may cause decreased mental status, walking disturbances, and dizziness, particularly at very high doses. These symptoms are usually reversible within a few days upon dose reduction or discontinuation of therapy.

Bone marrow function may be suppressed with ACTIMMUNE, and decreased production of cells important to the body may occur. This effect, which can be severe, is usually reversible when the drug is discontinued or the dose is reduced.

Taking ACTIMMUNE may cause reversible changes to your liver function, particularly in patients less than 1 year old. Your doctor should monitor your liver function every 3 months, and monthly in children under 1 year.

In rare cases, ACTIMMUNE can cause severe allergic reactions and/or rash. If you experience a serious reaction to ACTIMMUNE, discontinue it immediately and contact your doctor or seek medical help.

What should I tell my healthcare provider?

Be sure to tell your doctor about all the medications you are taking.

Tell your doctor if you:

  • are pregnant or plan to become pregnant or plan to nurse
  • have a cardiac condition such as irregular heartbeat, heart failure, or decreased blood flow to your heart
  • have a history of seizures or other neurologic disorders
  • have, or have had, reduced bone marrow function. Your doctor will monitor these cells with blood tests at the beginning of therapy and at 3-month intervals on ACTIMMUNE therapy

What are the side effects of ACTIMMUNE?

The most common side effects with ACTIMMUNE are "flu-like" symptoms such as fever, headache, chills, muscle pain, or fatigue, which may decrease in severity as treatment continues. Bedtime administration of ACTIMMUNE may help reduce some of these symptoms. Acetaminophen may be helpful in preventing fever and headache.

What other medications might interact with ACTIMMUNE?

Some drugs may interact with ACTIMMUNE to potentially increase the risk of damage to your heart or nervous system, such as certain chemotherapy drugs. Tell your doctor about all other medications you are taking.

Avoid taking ACTIMMUNE at the same time as a vaccination.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088. You may also contact the Horizon Pharma Medical Information Department toll-free at 1-866-479-6742 or medicalinformation@horizonpharma.com.

The risk information provided here is not comprehensive. To learn more, talk about ACTIMMUNE with your healthcare provider or pharmacist. The FDA-approved product labeling can be found at http://www.ACTIMMUNE.com or 1-866-479-6742.