Watch how to take ACTIMMUNE® to start lowering the risk of serious infections

See how to measure each dose, where to inject, and how to give an injection.

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Starting ACTIMMUNE® for chronic granulomatous disease (CGD)

ACTIMMUNE® (Interferon gamma-1b) is a medicine that is injected under the skin. It helps lower the risk of serious infections* related to chronic granulomatous disease (CGD). This means you can spend less time in the hospital and more time enjoying your life. ACTIMMUNE® works best when you take it exactly as your doctor told you to. The most common side effects seen with ACTIMMUNE® are flu-like symptoms such as fever, headache, chills, muscle pain, or fatigue (tiredness). These may decrease as treatment continues.

Important tips when starting ACTIMMUNE®

Take ACTIMMUNE®  (Interferon gamma-1b) 3 times a week calendar icon

It should be taken
3 times a week, at the
same time each day.

ACTIMMUNE®  (Interferon gamma-1b) injection icon

It may be self-injected
or given by a caregiver.

The injection site should be
rotated so that the skin has
time to heal.

Refrigerate ACTIMMUNE® (Interferon gamma-1b) icon

It should be refrigerated
(not frozen).

It should not be left at room temperature for longer than
12 hours.

 

Choosing an injection site

When injecting ACTIMMUNE®, choose a site that’s padded by some fat below the skin. Look for places like the thighs, back of the upper arm, or abdomen (stomach area). You should also change the site with every injection. This gives the skin time to heal.

Where to inject ACTIMMUNE® (Interferon gamma-1b) diagram

IMPORTANT:

Don’t take ACTIMMUNE® until a healthcare professional has given you detailed instructions and shown you how.

Free injection training is part of your support services

You may be nervous to give yourself or your loved one injections. Or maybe you just want to make sure you’re injecting correctly. Free injection training is offered by a CGD nurse educator through the Clinical Nurse Educator Program. This program is available to all ACTIMMUNE® patients. Also, a full network of services and support will help with:

  • Getting ACTIMMUNE® delivered to you
  • Working with your insurance provider
  • Scheduling needle and syringe pickup and disposal program
  • And much more

Discover all of the benefits of this support program.

*An infection is serious if you have to go to the hospital and get intravenous (IV) antibiotics.

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Your support team

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Important Safety Information

What is ACTIMMUNE® (Interferon gamma-1b) used for?

ACTIMMUNE® is part of a drug regimen used to treat Chronic Granulomatous Disease, or CGD. CGD is a genetic disorder, usually diagnosed in childhood, that affects some cells of the immune system and the body's ability to fight infections effectively.

Important Safety Information

What is ACTIMMUNE® (Interferon gamma-1b) used for?

ACTIMMUNE® is part of a drug regimen used to treat Chronic Granulomatous Disease, or CGD. CGD is a genetic disorder, usually diagnosed in childhood, that affects some cells of the immune system and the body's ability to fight infections effectively. CGD is often treated (though not cured) with antibiotics, antifungals, and ACTIMMUNE.

ACTIMMUNE is also used to slow the worsening of severe, malignant osteopetrosis (SMO). SMO is a genetic disorder that affects normal bone formation and is usually diagnosed in the first few months after birth.

When should I not take ACTIMMUNE?

Don't use ACTIMMUNE if you are allergic to interferon-gamma, E coli-derived products, or any ingredients contained in the product.

What warnings should I know about ACTIMMUNE?

At high doses, ACTIMMUNE can cause (flu-like) symptoms, which may worsen some pre-existing heart conditions.

ACTIMMUNE may cause decreased mental status, walking disturbances, and dizziness, particularly at very high doses. These symptoms are usually reversible within a few days upon dose reduction or discontinuation of therapy.

Bone marrow function may be suppressed with ACTIMMUNE, and decreased production of cells important to the body may occur. This effect, which can be severe, is usually reversible when the drug is discontinued or the dose is reduced.

Taking ACTIMMUNE may cause reversible changes to your liver function, particularly in patients less than 1 year old. Your doctor should monitor your liver function every 3 months, and monthly in children under 1 year.

In rare cases, ACTIMMUNE can cause severe allergic reactions and/or rash. If you experience a serious reaction to ACTIMMUNE, discontinue it immediately and contact your doctor or seek medical help.

What should I tell my healthcare provider?

Be sure to tell your doctor about all the medications you are taking.

Tell your doctor if you:

  • are pregnant or plan to become pregnant or plan to nurse
  • have a cardiac condition such as irregular heartbeat, heart failure, or decreased blood flow to your heart
  • have a history of seizures or other neurologic disorders
  • have, or have had, reduced bone marrow function. Your doctor will monitor these cells with blood tests at the beginning of therapy and at 3-month intervals on ACTIMMUNE therapy

What are the side effects of ACTIMMUNE?

The most common side effects with ACTIMMUNE are "flu-like" symptoms such as fever, headache, chills, muscle pain, or fatigue, which may decrease in severity as treatment continues. Bedtime administration of ACTIMMUNE may help reduce some of these symptoms. Acetaminophen may be helpful in preventing fever and headache.

What other medications might interact with ACTIMMUNE?

Some drugs may interact with ACTIMMUNE to potentially increase the risk of damage to your heart or nervous system, such as certain chemotherapy drugs. Tell your doctor about all other medications you are taking.

Avoid taking ACTIMMUNE at the same time as a vaccination.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088. You may also contact the Horizon Pharma Medical Information Department toll-free at 1-866-479-6742 or medicalinformation@horizonpharma.com.

The risk information provided here is not comprehensive. To learn more, talk about ACTIMMUNE with your healthcare provider or pharmacist. The FDA-approved product labeling can be found at http://www.ACTIMMUNE.com or 1-866-479-6742.