Approved Uses and Important Safety Information

What is ACTIMMUNE® (Interferon gamma-1b) used for?

ACTIMMUNE is used to treat chronic granulomatous disease, or CGD. CGD is a genetic disorder, usually diagnosed in childhood, that affects some cells of the immune system and the body’s risk of serious infection

ACTIMMUNE is also used to slow the worsening of severe, malignant osteopetrosis (SMO). SMO is a genetic disorder that affects normal bone formation and is usually diagnosed in the first few months after birth.

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Amgen By your side program Amgen By your side program

Amgen By Your Side program

Find one-on-one patient support.

CASEY, lives with X-linked CGD; ANDREA, Clinical Nurse Educator

Amgen By your side Amgen By your side

For people prescribed ACTIMMUNE® (Interferon gamma-1b), Amgen By Your Side is a program with dedicated team members who take a personalized approach to meeting the unique needs of each patient.

One-on-one support

Irma, CNE: My name is Irma. I’m the clinical nurse educator.

When I go to the patient’s house, the first thing I do is I introduce myself and my role and why I’m there for that day. I give ‘em an opportunity to just share everything that they’ve been through.

Jeannie: I’m Jeannie, the mother of Thaddeus. My son is 9 years old, and he was diagnosed with CGD at 6 years old.

The great thing about the support services is that it helps you not to feel alone. Just having that person that you know that you can call, and they can come and visit, and they can get to know your child and know you.

Irma We offer education, support, and advocacy. They can pick up the phone and call us. We’re there with them.

Jeannie: One of the most important things is when she described the CGD to Thaddaeus to help him understand what was wrong with his system, what caused it. That it wasn’t his fault.

Irma: I let them know that it’s an inherited primary immunodeficiency disease. It affects the child’s ability to fight infection. It doesn’t mean that they have to be isolated from the world. It doesn’t affect who they are. They just need to be careful.

Jeannie: I encourage any new families to take advantage of the support services, ‘cause the support team is fantastic.

With Amgen By Your Side, you’ll have a support team that includes a dedicated Clinical Nurse Educator (CNE) to guide and support you through every step of your journey. Together, they will:

Connect Connect

Connect

You will be paired with a CNE who will be there to support you throughout your treatment when you need it.

Coordinate Coordinate

Coordinate

The Amgen By Your Side team will work with you and your healthcare team to make sure nonmedical, logistical efforts are coordinated properly.

Champion Champion

Champion

Your CNE will be your point of contact and help you build confidence through your treatment.

  • Get nonmedical educational support
  • Avoid surprises at the start of treatment by talking about what to expect
  • Discuss how your new treatment can fit into your routine and meet your goals
  • Understand financial assistance options
  • Learn about the insurance process
  • Coordinate delivery with the specialty pharmacy to schedule shipments of your medicine
  • Get injection training and support
  • Connect to a sharps disposal program for easy needle and syringe pickup and disposal
  • Receive refill reminders to help you stay on ACTIMMUNE as your doctor has instructed
  • Connect to advocacy groups for more support and to inform you of events in your area
Enroll Enroll

ENROLLING IS EASY! Call 1-844-469-4297 or sign up through your doctor’s office. You can also visit www.amgenbyyourside.com/actimmune/patient for more information and resources specific to CGD and ACTIMMUNE.

MEET OTHERS WITH CGD

When living with a rare condition, it can be helpful to know you’re not alone. Hear stories about taking ACTIMMUNE and more.

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FIND YOUR LOCAL CARE TEAM

Your care team could include different specialists. Use the CGD Specialist Finder to locate the support you need.

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Next up: Get connected
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Approved Uses and Important Safety Information

What is ACTIMMUNE® (Interferon gamma-1b) used for?

ACTIMMUNE is used to treat chronic granulomatous disease, or CGD. CGD is a genetic disorder, usually diagnosed in childhood, that affects some cells of the immune system and the body’s ability to fight infections effectively.

ACTIMMUNE is also used to slow the worsening of severe, malignant osteopetrosis (SMO). SMO is a genetic disorder that affects normal bone formation and is usually diagnosed in the first few months after birth.

When should I not take ACTIMMUNE?

Do not use ACTIMMUNE if you are allergic to interferon gamma, E. coli-derived products, or any ingredients contained in the product.

What warnings should I know about ACTIMMUNE?

ACTIMMUNE can cause flu-like symptoms. At high doses, the resulting symptoms may worsen some pre-existing heart conditions.

ACTIMMUNE may cause decreased mental status, such as confusion, depression, and hallucinations. It may also cause difficulty walking and dizziness, particularly at high doses. These symptoms usually resolve a few days after reducing the amount of ACTIMMUNE you take, or if you are no longer taking it at all, as prescribed by your doctor.

Use of ACTIMMUNE may affect bone marrow function and may limit the production of cells important to your body. This can be severe and usually goes away after reducing the amount of ACTIMMUNE you take or if you stop taking it entirely as prescribed by your doctor.

Taking ACTIMMUNE may cause reversible changes to your liver function, particularly in patients less than 1 year old. Your doctor should monitor your liver function every 3 months, and monthly in children under 1 year of age.

In rare cases, ACTIMMUNE can cause severe allergic reactions and/or rash. If you experience a serious reaction to ACTIMMUNE, stop taking it immediately and contact your doctor or seek medical help.

What should I tell my healthcare provider?

Be sure to tell your doctor about all the medications you are taking.

Tell your doctor if you:

  • are pregnant or plan to become pregnant or plan to nurse
  • have a heart condition such as irregular heartbeat, heart failure, or decreased blood flow to your heart
  • have a history of seizures or other neurologic disorders
  • have, or have had, reduced bone marrow function. Your doctor will monitor these cells with blood tests at the beginning of therapy and every 3 months while you are taking ACTIMMUNE

What are the side effects of ACTIMMUNE?

The most common side effects with ACTIMMUNE are "flu-like" symptoms such as fever, headache, chills, muscle pain, or fatigue, which may decrease the longer you take ACTIMMUNE. Taking ACTIMMUNE at bedtime may help with these symptoms, and acetaminophen may help prevent fever and headache.

What other medications might interact with ACTIMMUNE?

Some drugs, like certain chemotherapy drugs, may interact with ACTIMMUNE and could make it more likely that your heart or nervous system could be damaged. Tell your doctor about all the medicines you take.

Avoid taking ACTIMMUNE at the same time as a vaccination.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/safety/medwatch, or call 1-800-FDA-1088.

The risk information provided here is not comprehensive. To learn more, talk about ACTIMMUNE with your healthcare provider or pharmacist. The FDA-approved product labeling can be found at www.ACTIMMUNE.com or 1-866-479-6742.

Approved Uses and Important Safety Information

What is ACTIMMUNE® (Interferon gamma-1b) used for?

ACTIMMUNE is used to treat chronic granulomatous disease, or CGD. CGD is a genetic disorder, usually diagnosed in childhood, that affects some cells of the immune system and the body’s ability to fight infections effectively.

ACTIMMUNE is also used to slow the worsening of severe, malignant osteopetrosis (SMO). SMO is a genetic disorder that affects normal bone formation and is usually diagnosed in the first few months after birth.

When should I not take ACTIMMUNE?

Do not use ACTIMMUNE if you are allergic to interferon gamma, E. coli-derived products, or any ingredients contained in the product.

What warnings should I know about ACTIMMUNE?

ACTIMMUNE can cause flu-like symptoms. At high doses, the resulting symptoms may worsen some pre-existing heart conditions.

ACTIMMUNE may cause decreased mental status, such as confusion, depression, and hallucinations. It may also cause difficulty walking and dizziness, particularly at high doses. These symptoms usually resolve a few days after reducing the amount of ACTIMMUNE you take, or if you are no longer taking it at all, as prescribed by your doctor.

Use of ACTIMMUNE may affect bone marrow function and may limit the production of cells important to your body. This can be severe and usually goes away after reducing the amount of ACTIMMUNE you take or if you stop taking it entirely as prescribed by your doctor.

Taking ACTIMMUNE may cause reversible changes to your liver function, particularly in patients less than 1 year old. Your doctor should monitor your liver function every 3 months, and monthly in children under 1 year of age.

In rare cases, ACTIMMUNE can cause severe allergic reactions and/or rash. If you experience a serious reaction to ACTIMMUNE, stop taking it immediately and contact your doctor or seek medical help.

What should I tell my healthcare provider?

Be sure to tell your doctor about all the medications you are taking.

Tell your doctor if you:

  • are pregnant or plan to become pregnant or plan to nurse
  • have a heart condition such as irregular heartbeat, heart failure, or decreased blood flow to your heart
  • have a history of seizures or other neurologic disorders
  • have, or have had, reduced bone marrow function. Your doctor will monitor these cells with blood tests at the beginning of therapy and every 3 months while you are taking ACTIMMUNE

What are the side effects of ACTIMMUNE?

The most common side effects with ACTIMMUNE are "flu-like" symptoms such as fever, headache, chills, muscle pain, or fatigue, which may decrease the longer you take ACTIMMUNE. Taking ACTIMMUNE at bedtime may help with these symptoms, and acetaminophen may help prevent fever and headache.

What other medications might interact with ACTIMMUNE?

Some drugs, like certain chemotherapy drugs, may interact with ACTIMMUNE and could make it more likely that your heart or nervous system could be damaged. Tell your doctor about all the medicines you take.

Avoid taking ACTIMMUNE at the same time as a vaccination.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/safety/medwatch, or call 1-800-FDA-1088.

The risk information provided here is not comprehensive. To learn more, talk about ACTIMMUNE with your healthcare provider or pharmacist. The FDA-approved product labeling can be found at www.ACTIMMUNE.com or 1-866-479-6742.

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The information provided in this site is intended only for residents of the United States. The health information contained herein is provided for educational purposes only and is not intended to replace discussions with a healthcare provider.